I used to be a road warrior for five years living out of Residence Inn in the larger cities and three star hotels when that was all that was available. I had a large three state route that I slowly crawled around and went back to a city and went to a small town tavern that I was very familiar with from my last trip a few months prior.
Well, They changed the mens and womens rooms around, and I went into the womens room without knowing it.
The locals had a fun time with me and held the door shut and called me a pervert and knew I was disorientated. They eventually stopped holding the door and I flew out (half drunk) and took over a table and they all had a good chuckle.
It was a small town of about 8,000 and they all knew that there was a remodel and the womens and mens was changed to be the *OPPOSITE* locations.
Ever since then, I'm very careful to get it right.